Objective: T. gondii, Rubella, and Cytomegalovirus infections can lead to significant complications in women of reproductive age. This study aimed to evaluate the seroprevalence of T. gondii, Rubella, and Cytomegalovirus among women of childbearing age in Muğla, Türkiye. Methods: The study included cases aged 16-55 years who were tested for Anti-CMV IgM, IgG, Avidity; Anti-Rubella IgM, IgG; Anti-Toxoplasma IgM, IgG and Avidity between January 2019 and January 2025. The analyses were performed using the Roche Cobas e 601 analyzer (Roche, Germany). Results: The seroprevalence rates were as follows: Toxoplasma IgM 1.6%, Toxoplasma IgG 19.8%, with 45.2% of IgG-positive cases exhibiting low avidity. Rubella IgM was detected in 0.7% and Rubella IgG in 92.9% of the cases. CMV IgM was positive in 1.4% and CMV IgG in 97%, with 4.3% of IgG-positive cases showing low avidity. Positivity for Toxoplasma IgM, Rubella IgM, and CMV IgM was highest in the 31–40 age group. Toxoplasma IgG positivity was most prevalent in women over 40 years of age, while Rubella IgG and CMV IgG seroprevalences were highest among women aged 20 years and under. The highest number of positive cases were observed in 2023 for Toxoplasma IgM (n=38), Rubella IgM (n=14), and CMV IgM (n=33). Conclusion: There is currently no consensus regarding the routine screening of pregnant women for T. gondii, Rubella, and CMV infections. Physicians should consider regional seroprevalences when making screening decisions. Therefore, it is essential that each region has access to its own epidemiological data to guide effective screening strategies. Keywords: Avidity, CMV, seroprevalence, Rubella, Toxoplasma gondii.
Karabey et al. (Tue,) studied this question.