Addressing the challenges of low resource-use efficiency and supply–demand mismatch in Hami melon production, this study investigated the interactive effects of irrigation and fertilization to identify an optimal regime that balances yield, water conservation, and resource-use efficiency (i.e., water use efficiency and fertilizer partial factor productivity). A greenhouse experiment was conducted in Hami, Xinjiang, employing a two-factor design with five irrigation levels (W1–W5: 60–100% of full irrigation) and three fertilization levels (F1–F3: 80–100% of standard rate), replicated three times. Growth parameters, yield, water use efficiency (WUE), and partial factor productivity of fertilizer (PFP) were evaluated and comprehensively analyzed using the entropy-weighted TOPSIS method, regression analysis, and the NSGA-II multi-objective genetic algorithm. Results demonstrated that irrigation volume was the dominant factor influencing growth and yield. The W4F3 treatment (90% irrigation with 100% fertilization) achieved the optimal outcome, yielding 75.74 t ha−1—a 9.71% increase over the control—while simultaneously enhancing WUE and PFP. Both the entropy-weighted TOPSIS evaluation (C = 0.998) and regression analysis (optimal irrigation level at w = 0.79, ~90% of full irrigation) identified W4F3 as superior. NSGA-II optimization further validated this, generating Pareto-optimal solutions highly consistent with the experimental optimum. The model-predicted optimal regime for greenhouse Hami melon in Xinjiang is an irrigation amount of 3276 m3 ha−1 and a fertilizer application rate of 814.8 kg ha−1. This regime facilitates a 10% reduction in irrigation water and a 5% reduction in fertilizer input without compromising yield, alongside significantly improved resource-use efficiencies.
Song et al. (Fri,) studied this question.