A rare case of angiomatoid fibrous histiocytoma in the lung exhibited ALK protein expression without ALK rearrangement or amplification.
Highlights a rare case of primary pulmonary angiomatoid fibrous histiocytoma where ALK protein expression occurs without ALK rearrangement or amplification.
Absolute Event Rate: 0% vs 0%
We encountered a rare case of AFH arising from the left upper pulmonary lobe. Its diagnosis required a combination of histopathological examination, immunohistochemistry, and FISH. ALK protein expression is commonly observed in AFH; however, the underlying mechanism remains unclear, as it does not appear to result from ALK rearrangement or amplification.
Liu et al. (Tue,) reported a other. A rare case of angiomatoid fibrous histiocytoma in the lung exhibited ALK protein expression without ALK rearrangement or amplification.