What question did this study set out to answer?

To identify inflammatory molecular endotypes in the vitreous humor and plasma of proliferative diabetic retinopathy patients.

January 23, 2026Open Access

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Olink Proteomic Profiling of Vitreous Humor and Plasma From Proliferative Diabetic Retinopathy Patients Identifies a Novel Inflammatory Molecular Endotype

Key Points

To identify inflammatory molecular endotypes in the vitreous humor and plasma of proliferative diabetic retinopathy patients.
Analyzed proteomic profiles of vitreous humor and plasma from patients with proliferative diabetic retinopathy.
Conducted endotyping analysis on vitreous samples to identify unique patient populations.
Examined inflammatory pathways associated with patient stratification.
Significant differences in proteomic profiles observed, with notable distinctions in vitreous samples.
CA family members identified as potential therapeutic targets for PDR.
Unique inflammatory pathways including CCL, CXCL, IL6, and IL18 enriched in specific patient populations.

Abstract

Significant differences in proteomic profiles were observed in PDR patients, especially in vitreous samples, with CA family members identified as potential therapeutic targets for PDR. Endotyping analysis of vitreous samples uncovered unique patient population with enriched CCL/CXCL/IL6/IL18 inflammatory pathways, highlighting the significance of local protein signature changes in PDR disease heterogeneity and its potential applications in patient stratification and therapeutic treatment.

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View Full Paper

Olink Proteomic Profiling of Vitreous Humor and Plasma From Proliferative Diabetic Retinopathy Patients Identifies a Novel Inflammatory Molecular Endotype

Key Points

Abstract

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