Amplifying the “In Situ Vaccination” of BET Inhibition via Autophagy Blockade: Mechanism and Local Delivery in OSCC

Key Points

• Investigate the effects of BET inhibition and autophagy blockade on immunogenicity in OSCC.
• Examined the role of BET inhibitors in inducing immunogenic cell death.
• Assessed the impact of autophagy blockade on tumor microenvironment.
• Utilized local delivery systems for enhanced treatment efficacy.
• BET inhibition combined with autophagy blockade increased immunogenicity.
• Enhanced local immune response was observed in the tumor microenvironment.
• Significant reduction in tumor recurrence and metastasis rates.