Nano-bioparticles: Fighting cancer with targeted nanotherapy Dr LK Medina-Kauwe developed a bioengineered delivery system to treat resistant and metastatic tumors, highlighting the potential of nano-bioparticles to enhance cancer therapy by targeting specific tumor characteristics and overcoming treatment barriers. Repurposing parts of viruses, growth factors, and nucleic acid-binding proteins has led to the development of a bioengineered therapeutic delivery vehicle being evaluated as a cancer-specific molecular missile. Dr LK Medina-Kauwe combined the cell-binding, membrane-penetration, and intracellular trafficking functions of pathogen proteins and naturally occurring protein ligands to develop a biologically based tumor-homing platform technology designed to self-assemble with and selectively deliver therapeutic molecules to resistant and metastatic tumors. (1-2) These molecular missiles are comprised of nano-sized biologically derived particles, or nano-bioparticles (NBPs; Fig. 1) that can self-assemble with a variety of therapeutic payloads, including:
Lali Medina-Kauwe (Thu,) studied this question.