What question did this study set out to answer?

To investigate the effectiveness of CuTCPP-MOF in enhancing prostate cancer therapy through chemodynamic and photodynamic effects.

January 23, 2026

Combination prostate cancer therapy via CuTCPP-MOF-mediated chemodynamic and photodynamic effects

Key Points

To investigate the effectiveness of CuTCPP-MOF in enhancing prostate cancer therapy through chemodynamic and photodynamic effects.
Utilized CuTCPP-MOF to release acidic Cu 2+ /Cu + ions
Depleted glutathione (GSH) levels in tumor cells
Activated the therapy with light to generate singlet oxygen (1 O2)
Assessed tumor cell apoptosis in response to amplified oxidative stress
CuTCPP-MOF successfully released Cu 2+ /Cu +, leading to GSH depletion
Increased levels of ˙OH radicals were observed
Light activation effectively generated singlet oxygen, resulting in higher oxidative stress
Significant promotion of tumor cell apoptosis was recorded.

Abstract

CuTCPP-MOF enables synergistic CDT/PDT: acidic Cu 2+ /Cu + release depletes GSH and produces ˙OH radicals, while light activation generates singlet oxygen ( 1 O 2 ), amplifying oxidative stress and promoting tumor cell apoptosis.

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