Abstract Background and aims Despite the rapid development of medical therapies, ileocolonic resection (ICR) remains a fundamental modality in the multidisciplinary treatment of patients with Crohn’s disease (CD). Surgery in CD is not curative and postoperative recurrence is observed in up to 50% of patients within 6 months, possibly leading to exposure to medical treatment, subsequent re-resection and decreased quality of life. The current level of evidence for proposed postoperative treatment strategies is low, causing over-treatment of patients at low risk of recurrence and under-treatment of patients at high risk. An extensive, well-characterized dataset of CD patients after ICR would be valuable to investigate the postoperative CD disease course and improve postoperative treatment strategies for this large population of CD patients. Furthermore, the development of postoperative recurrent inflammation can be seen as “new onset” inflammation, making the postoperative CD population specifically valuable for future research e.g. to explore new biomarkers in serum, blood or the resection specimen. This study aims to combine three ongoing prospective registries including postoperative CD patients after ICR. Methods The data registry system Castor will be used to merge available registries and will be used for convenient and safe data inclusion and storage. International registries will be merged using standardized variables, definitions and study outcomes to create uniformity. Subsequently, this large, well-defined registry will be further expanded by including new international study sites and prospectively including patients at all participating centers. Anticipated impact One of the short-term benefits of this data registry may be the identification of new clinical, biochemical or histological markers for recurrence, and the possibility to validate identified predictors across different countries and regions. The major long term expected benefit derived from this registry is the improvement of postoperative CD patient care, by providing real-world, high-quality, prospectively collected data on the peri and postoperative CD disease course
Vries et al. (Thu,) studied this question.
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