Deciphering the Key Toxicants and Hepatotoxicity Mechanisms of Epimedii Folium and its Preparations via Network Toxicology and Molecular Docking.

Key Points

• The central aim is to identify the toxicants in Epimedii Folium and understand their effects on liver health.
• Utilized network toxicology to analyze toxic effects
• Conducted molecular docking to study interactions with liver cells
• Compared formulations XLGB and ZGGJ for toxicological differences
• Identified specific toxicants contributing to liver damage
• Showed synergistic toxic effects between Epimedii Folium and formulations
• Provided insights for safer traditional medicine practices