Mechanistic insights into dietary CuO nanoparticles (CuO NPs)-induced hepatic lipotoxicity: The critical role of the Ccs/Mek1/Erk1/2/Pparα pathway and mitochondrial oxidative stress

Key Points

• The aim is to explore how CuO nanoparticles induce lipotoxicity in the liver through specific molecular pathways.
• Analyzed the impact of CuO nanoparticles on liver cells
• Investigated the Ccs/Mek1/Erk1/2/Pparα signaling pathway
• Assessed mitochondrial oxidative stress levels
• CuO nanoparticles significantly increased lipotoxicity in liver cells
• Activation of the Ccs/Mek1/Erk1/2/Pparα pathway was observed
• Mitochondrial oxidative stress was elevated in response to CuO exposure