Fecal microbiota transplantation promotes Wnt3a-mediated hippocampal neurogenesis in a rat model of chronic cerebral hypoperfusion

Key Points

• The aim is to evaluate how fecal microbiota transplantation influences neurogenesis through Wnt3a in a rat model of chronic cerebral hypoperfusion.
• Analyzed the effects of fecal microbiota transplantation in a rat model of chronic cerebral hypoperfusion.
• Measured levels of Wnt3a and neurogenesis in the hippocampus after intervention.
• Compared neurogenesis markers pre- and post-FMT.
• Fecal microbiota transplantation significantly increased Wnt3a levels in the hippocampus.
• Enhanced neurogenesis was observed in the hippocampus following FMT.
• Protection against neurodegenerative insults was demonstrated in the chronic cerebral hypoperfusion model.