This research aims to understand how hypoxia inducible factor-1α affects orthodontic tooth movement in the context of a high-salt diet.
Utilized a mouse model to analyze orthodontic tooth movement (OTM).
Assessed the effects of a high-salt diet on OTM rates.
Evaluated the role of myeloid cell-derived HIF1α in OTM under high-salt conditions.
A high-salt diet and lack of HIF1α both resulted in increased OTM.
OTM was primarily influenced by high-salt conditions regardless of HIF1α levels in myeloid cells.
Abstract
A high-salt diet and the absence of HIF1α both lead to increased OTM. In the tested OTM model, exposure to high-salt conditions was largely independent of myeloid cell-derived HIF1α.