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January 25, 2026Open Access

Prognostic nomograms for predicting overall and cancer-specific survival in acute erythroid leukemia: a SEER-based study

Key Points

This research aims to create prognostic nomograms for predicting overall and cancer-specific survival in acute erythroid leukemia patients.
Developed SEER-based nomograms for overall survival (OS) and cancer-specific survival (CSS).
Conducted internal validation to assess nomogram performance.
Identified limitations due to the absence of molecular data such as TP53 mutations.
The nomograms demonstrated reliable performance in predicting OS and CSS.
The models require external validation before clinical application.
Limited biological insight due to lack of molecular data.

Abstract

We developed and validated novel SEER-based nomograms for predicting OS and CSS in patients with AEL, which demonstrated reliable performance in internal validation. However, the lack of molecular data (e.g., TP53 mutations) limits the biological interpretability of the models. External validation is required before clinical implementation.

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Cite This Study

Ma et al. (Fri,) studied this question.

synapsesocial.com/papers/6975b28afeba4585c2d6df89 https://doi.org/https://doi.org/10.1007/s12672-026-04465-8

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