Interventricular septum thickness was greater in infants of diabetic mothers, with 32.5% showing asymmetric septal hypertrophy and elevated NT-proBNP and IMA levels.
Do infants of diabetic mothers have altered echocardiographic parameters and elevated cord blood cardiac biomarkers compared to healthy term newborns?
Infants of diabetic mothers exhibit subclinical cardiac stress and dysfunction, evidenced by increased septal thickness, altered tissue Doppler parameters, and elevated cord blood NT-proBNP and IMA.
Absolute Event Rate: 0% vs 0%
Abstract Background Maternal diabetes mellitus (DM) significantly affects fetal cardiac and placental structure and function. This study aimed to assess structural and functional cardiac changes in infants of diabetic mothers (IDMs) using echocardiographic data and cord blood cardiac biomarkers. Methods M-mode and pulsed-wave tissue Doppler imaging (PW-TDI) echocardiography along with cord blood cardiac markers were evaluated in 40 IDMs and 40 healthy term newborns. Cardiac biomarkers included troponin T (Trop-T), N-terminal pro-brain natriuretic peptide (NT-proBNP), and ischemia-modified albumin (IMA). Results Among the diabetic mothers, 87.5% had gestational diabetes mellitus (GDM) and 12.5% had type 1 diabetes mellitus (T1DM). Interventricular septum (IVS) thickness was significantly greater in the IDM group. Of the IDMs, 32.5% had asymmetric septal hypertrophy. Mid-septal tissue Doppler Imaging (TDI) parameters showed significantly altered velocities and time intervals. NT-proBNP and IMA levels were significantly elevated in the IDMs group, while Trop-T was not statistically different. No correlation was found between TDI parameters and biomarker levels. Conclusion Cardiac dysfunction and elevated cord blood biomarkers in IDMs reflect subclinical stress. These findings support the utility of TDI and biochemical markers for early cardiac assessment in IDMs. Larger studies are needed to validate the use of these markers for routine screening and to better understand their pathophysiological significance.
Taşkın et al. (Fri,) reported a other. Interventricular septum thickness was greater in infants of diabetic mothers, with 32.5% showing asymmetric septal hypertrophy and elevated NT-proBNP and IMA levels.