The EV-A71 vaccine reduced HFMD transmission in spring but not in fall, with new predominant strains emerging in southern China post-vaccination.
Does the EV-A71 vaccine impact the epidemic pattern and strain replacement of hand, foot, and mouth disease?
The EV-A71 vaccine altered HFMD epidemic patterns by reducing spring transmission, but the emergence of new strains necessitates enhanced surveillance and multivalent vaccines.
Absolute Event Rate: 0% vs 0%
The epidemic pattern of HFMD has shifted after the vaccination campaign. While the EV-A71 vaccine reduced transmission in the spring season, it had little impact on reducing cases in fall. Meanwhile, potential new predominant strains have emerged. Public health system should incorporate enhanced surveillance by including whole genome sequencing to ensure close monitoring of serotype replacement and to assess the need for multivalent vaccines across Southern China.
Hou et al. (Thu,) reported a other. The EV-A71 vaccine reduced HFMD transmission in spring but not in fall, with new predominant strains emerging in southern China post-vaccination.