Targeted biologics for chronic rhinosinusitis with nasal polyps: efficacy and safety comparison of eight monoclonal antibodies via network meta-analysis.

Key Points

• The aim is to evaluate the efficacy and safety of eight monoclonal antibodies in the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP).
• Conducted a network meta-analysis of eight monoclonal antibodies
• Compared their effects against placebo
• Assessed safety profiles of all treatments.
• All biologics showed greater efficacy than placebo
• IL-4 receptor alpha inhibitors had the most significant and consistent benefits
• All treatments maintained favorable safety profiles for long-term use.