ABSTRACT Dopamine is one of the key neurotransmitters involved in the regulation of cognitive functions, and its dysregulation has been associated with various psychological and neurological disorders. Hence, we have focused on creating a cost effective viable polyglutamic acid immobilized molybdenum oxide nano rods (MoO 3 NR) anchored on carbon paste electrode (poly glu/MoO 3 NR/CPE) for enhancing the detection limit of dopamine. MoO 3 NR were hydrothermally synthesized and characterized using XRD, TEM, HRTEM, XPS, SAED, and EDS to assess their crystallinity, elemental composition, and surface morphology relevant to electrochemical performance. Poly glutamic acid is prepared using electro polymerization of glutamic acid chosen for its skin friendly nature. The CV, EIS, and DPV techniques were used for the assessment of fabricated electrode's electroanalytical performance, and sensitivity. The LOD and LOQ of dopamine from the present work was found to be as 0.0972, 0.324 µM, respectively. Simultaneous detection of DA and uric acid (UA) was conducted by DPV. This proposed sensor showed promising results in detecting DA in spiked buffer and human serum samples. In future, the present fabricated electrode can be expected for better monitoring of dopamine with interdisciplinary studies.
Rizwan et al. (Thu,) studied this question.