This study aims to compare the efficacy and adverse reactions of adenosine triphosphate (ATP) combined with microwave therapy and traditional glucocorticoid therapy for lichen sclerosus (LS) in women, providing a new reference for clinical management. This retrospective comparative study analyzed the clinical data of 120 women with LS who were treated in the Gynecology Outpatient Department of the Fourth Hospital of Shijiazhuang from December 2023 to December 2026. According to the treatment methods they received, the patients were divided into 4 groups: the control group (glucocorticoid therapy), the ATP group, the microwave group, and the combined group (ATP combined with microwave therapy), with 30 cases in each group. Clinical efficacy, symptom scores, adverse reactions, and recurrence rates were evaluated after 3 months of treatment. The total effective rate of the combined group was significantly higher than that of the other 3 groups ( P <.001). The combined group showed significantly lower symptom scores at 1 week, 1 month, 2 months, and 3 months after treatment compared with the other 3 groups ( P <.05). The incidence of adverse reactions in the combined group was significantly lower than that in the other 3 groups ( P <.05). During the 1-year follow-up, the recurrence rate of the combined group was also significantly lower than that of the other 3 groups ( P <.05). ATP combined with microwave therapy demonstrates superior clinical efficacy in relieving symptoms of LS, with fewer adverse reactions and a lower recurrence rate compared with traditional glucocorticoid therapy. As a noninvasive treatment approach, it provides a promising option for the clinical management of LS in women.
Pei et al. (Fri,) studied this question.