What question did this study set out to answer?

This research aims to develop a novel pathway for synthesizing 3-selenylated chromones using electrochemical methods.

January 25, 2026Open Access

Electrochemical Synthesis of 3-Selenyl-Chromones via Domino C(sp2)-H Bond Selenylation/Annulation of Enaminones

JBJoão M. BritoUniversidade Federal de Goiás IOIsabella M. e OliveiraUniversidade Federal de Goiás CMCassio A. O. Moraes

Key Points

This research aims to develop a novel pathway for synthesizing 3-selenylated chromones using electrochemical methods.
Utilized electrosynthesis for selenylation of enaminones
Explored a domino reaction involving C(sp2)-H bond manipulation
Tested various substrates and conditions
Scaled up the reaction to assess feasibility
Achieved good yields of 3-selenylated chromones
Demonstrated wide substrate compatibility and functional group tolerance
Indicated a possible cation pathway over a radical mechanism for the reaction

Abstract

Herein, we disclose a highly efficient pathway toward 3-selenylated chromone derivatives via electrosynthesis domino C(sp2)-H bond selenylation/cyclization/deamination of 2-hydroxyaryl enaminones with diselenides. This method showed mild conditions, easy operation, a wide substrate scope, and good functional group tolerance. Furthermore, this electrosynthesis strategy was amenable to scaling up the reaction. Additionally, the preliminary experiments revealed that this reaction probably proceeded via a cation pathway instead of a radical pathway.

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