Investigation of the Antiepileptic and Anti-inflammatory Effects of Empagliflozin on Penicillin-induced Epileptiform Activity in Rats.

Key Points

• This study aims to evaluate the effects of empagliflozin on seizure activity and inflammation in a rat model of epilepsy.
• Penicillin-induced epileptiform activity was used to assess seizure effects.
• Empagliflozin was administered to observe its impact on seizure onset and cytokine levels.
• Seizure waveforms and cytokine concentrations were measured post-treatment.
• Empagliflozin effectively delayed seizure onset compared to controls.
• It reduced seizure waveforms, indicating decreased epileptiform activity.
• The treatment modulated levels of pro-inflammatory cytokines, suggesting an anti-inflammatory effect.