Abstract Myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT) is the most commonly used and well-documented noninvasive method for diagnosis and risk stratification of coronary artery disease (CAD). The location and extent of ischemia can be reliably and semiquantitatively obtained using MPI, which plays an important role for patient management. The management of patients with mild ischemia detected on MPI using SPECT remains a subject of debate in the field of cardiology. The decision between invasive evaluation (e.g., coronary angiography with potential revascularization) and pharmacological treatment (e.g., antianginal drugs and statins) is complex and must be guided by both clinical and imaging findings. This study aims to compare the outcomes of invasive strategies versus pharmacological treatment in patients with mild ischemia as reported on SPECT MPI. The results highlight the nuanced benefits and limitations of each approach, emphasizing the need for personalized treatment decisions.
Safari et al. (Tue,) studied this question.