Cholestatic biomarkers and symptoms in primary sclerosing cholangitis: a post-hoc analysis of the DILSTENT

Key Points

• The aim is to investigate the link between alkaline phosphatase (ALP) levels and symptoms of cholestasis in primary sclerosing cholangitis.
• Post-hoc analysis of DILSTENT data
• Assessment of ALP levels
• Evaluation of pruritus symptom severity
• Significant association found between ALP levels and pruritus
• Supports ALP's role as a valid cholestatic marker
• Strengthens ALP's potential use as a surrogate endpoint in trials