High baseline D-dimer levels were associated with increased risk of all-cause mortality (HR = 2.35) and cardiovascular mortality (HR = 2.94) after PCI in CHD patients.
Do high baseline D-dimer levels predict adverse outcomes in patients with coronary heart disease after percutaneous coronary intervention?
High baseline D-dimer levels serve as a significant predictor of increased all-cause mortality, cardiovascular mortality, and MACE in patients with coronary heart disease undergoing PCI.
Absolute Event Rate: 0% vs 0%
Background: To investigate the association between baseline D-dimers (DD) and adverse outcomes after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD) by meta-analysis. Methods: Relevant literature was obtained by searching PubMed, Web of Science, Cochrance Library, and Embase until November 2024. The hazard ratio (HR) and 95% confidence interval (CI) were pooled for each study using either a fixed or random-effects model. The clinical outcomes analyzed were all-cause mortality, cardiovascular mortality, major adverse cardiovascular events (MACE), and revascularization. Results: A total of 10 articles were included in this meta-analysis. The results of meta-analysis showed that high baseline DD levels were associated with an increased risk of all-cause mortality (HR = 2.35, 95% CI: 1.78–3.10, P < .001), cardiovascular mortality (HR = 2.94, 95% CI: 1.99–4.33, P < .001), and MACE (HR = 1.74, 95% CI: 1.25–2.42, P = .001) after PCI in patients with CHD. However, no association was found between baseline DD level and revascularization risk (HR = 1.02, 95% CI: 0.76–1.37, P = .893). Conclusion: Baseline DD level can predict adverse clinical outcomes after PCI in patients with CHD. High baseline DD levels were significantly associated with an increased risk of all-cause mortality, cardiovascular mortality, and MACE.
Li et al. (Fri,) reported a other. High baseline D-dimer levels were associated with increased risk of all-cause mortality (HR = 2.35) and cardiovascular mortality (HR = 2.94) after PCI in CHD patients.