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February 2, 2026Critical Reviews in Oncology/Hematology0 citationsOpen Access

Diagnostic and Prognostic Significance of Circulating HPV cfDNA in Cervical Cancer: A Systematic Review and Meta-analysis

PPPreetiparna ParidaManipal Academy of Higher Education AMAnkita MehtaManipal Academy of Higher Education ERElstin Anbu Raj

Key Points

This research aims to evaluate the diagnostic and prognostic significance of circulating HPV cfDNA in cervical cancer.
Conducted a systematic review of literature
Performed a meta-analysis of existing studies
Assessed the specificity and prognostic value of HPV cfDNA
HPV cfDNA demonstrated high specificity for cervical cancer detection
The prognostic value of HPV cfDNA was found to be strong
Supports clinical utility in treatment surveillance

Abstract

HPV cfDNA shows high specificity and strong prognostic value, supporting its clinical utility in cervical cancer detection and treatment surveillance.

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