MyeliMAP: A Microfluidic-Multielectrode Array Hybrid Platform to Investigate Oligodendrocyte Function in Human iPSC derived Brain-Like Networks

Key Points

• The aim is to explore oligodendrocyte function within human iPSC-derived brain-like networks using a novel platform.
• Developed a microfluidic-multielectrode array hybrid platform.
• Utilized human induced pluripotent stem cells (iPSCs) to create brain-like networks.
• Conducted electrophysiological recordings to assess oligodendrocyte activity.
• Demonstrated effective oligodendrocyte function through improved signal propagation.
• Showed enhanced metabolic support for neurons in the brain-like networks.
• Revealed potential implications for understanding CNS-related disorders.