What question did this study set out to answer?

The aim is to review key findings regarding LRRTMs and Slitrks in synaptic biology and identify unresolved questions for future research.

February 2, 2026Open Access

A decade of progress in understanding LRRTM and Slitrk synaptic cell-adhesion molecules

Key Points

The aim is to review key findings regarding LRRTMs and Slitrks in synaptic biology and identify unresolved questions for future research.
Comprehensive synthesis of research findings over the last 15 years on LRRTMs and Slitrks
Analysis of their roles in neural circuitry and functional mechanisms
Discussion of pathophysiological implications in neurological disorders
LRRTMs and Slitrks are critical for synaptic specificity and diversity
Their functional mechanisms in neural circuit assembly remain largely unresolved
Potential roles in various neurological disorders highlight the importance of further study

Abstract

For over a decade, synaptic cell-adhesion molecules (CAMs) have been recognized as fundamental determinants of neural circuit specificity and diversity. Among the CAMs, leucine-rich repeat (LRR)-containing transmembrane proteins have been established as crucial regulators of synaptic properties across diverse cell-types and brain regions. This minireview focuses on two families of LRR-containing CAMs: leucine-rich repeat transmembrane proteins (LRRTMs) and the Slit and Trk-like family (Slitrks). We provide a comprehensive synthesis of significant findings on LRRTMs and Slitrks since their initial characterization more than 15 years ago. Furthermore, we outline key unresolved questions to stimulate future studies on their functional mechanisms in neural circuit assembly and their pathophysiological roles in various neurological disorders.

A decade of progress in understanding LRRTM and Slitrk synaptic cell-adhesion molecules

Key Points

Abstract

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