Abstract Background Opioid use disorder (OUD) presents major challenges, especially when combined with chronic pain and psychiatric comorbidities. A 25‐year‐old woman with OUD, chronic pain, and major depressive disorder underwent an 8‐week protocol of intravenous ketamine infusions (0.5 mg/kg weekly) as an adjunct to opioid tapering. Results Methadone dosage was reduced by 50%, with improved pain and craving control, reduced withdrawal symptoms, and greater psychotherapy engagement. Discussion and Conclusions Ketamine‐assisted “bridge therapy” treatment may support opioid tapering in complex cases. Scientific Significance This is a novel report to document a multifaceted improvement in this specific comorbidity cluster.
Oliveira et al. (Wed,) studied this question.
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