Epigenetic silencing and pharmacological inhibition of EIF5A2 foster venetoclax sensitivity in acute myeloid leukaemia

Key Points

• This research aims to understand how EIF5A2 influences venetoclax sensitivity in acute myeloid leukaemia.
• Investigated EIF5A2 activity reduction via gene hypermethylation and pharmacological inhibition.
• Examined the effects of these interventions on venetoclax sensitivity in AML cells.
• Both hypermethylation and pharmacological inhibition of EIF5A2 increased venetoclax sensitivity.
• The study shows a direct relationship between EIF5A2 activity loss and enhanced drug effectiveness in AML.