Vitamin E Alleviates Oxidative Damage and Attenuates Ferroptosis Caused by Prolonged Contraction of the Ciliary Muscle by Activating ACOT7

Key Points

• The research aims to investigate how Vitamin E can reduce oxidative damage and ferroptosis in the ciliary muscle.
• Examined the effects of Vitamin E on oxidative stress in the ciliary muscle.
• Analyzed the activation of acetyl-coenzyme A thiosterase 7 (ACOT7).
• Assessed levels of ferroptosis-related markers in muscle contraction scenarios.
• Vitamin E significantly reduced oxidative stress in the ciliary muscle.
• Activating ACOT7 was linked to decreased ferroptosis levels.
• Prolonged muscle contraction resulted in notable oxidative damage, which Vitamin E effectively alleviated.