Photoradiolabeling of onartuzumab with 99m Tc and 188 Re-tricarbonyl for radiotheranostics of gastric cancer

Key Points

• To evaluate the effectiveness of photoradiolabeling on the monoclonal antibody onartuzumab using specific nuclides.
• Conducted light-induced bioconjugation of onartuzumab.
• Performed radiolabeling with the tricarbonyl chemistry of $^{99m}$ Tc and $^{188}$ Re.
• Utilized a matched pair of nuclides for enhanced therapeutic and diagnostic capabilities.
• Successfully labeled onartuzumab with $^{99m}$ Tc and $^{188}$ Re.
• Demonstrated improved targeting ability for gastric cancer therapies.
• Showed potential for combining both therapeutic and diagnostic functions in treatment.