Lower left ventricular ejection fraction ≤40% was independently associated with a 2.49-fold higher adjusted odds of moderate/severe cognitive impairment compared to >40%.
Is lower left ventricular ejection fraction associated with worse cognitive performance in adult patients?
HFrEF is independently associated with a 2.5-fold higher risk of moderate to severe cognitive impairment compared to patients without heart failure, an effect not observed in HFpEF or HFmrEF.
Absolute Event Rate: 0% vs 0%
Introduction: Studies suggest that stroke and hypoperfusion from heart failure (HF) may contribute to cognitive decline. However, the relationship between the HF subtypes and cognition remains poorly described in real-world populations. Hypothesis: We hypothesized that HF subtypes are differentially associated with cognitive impairment and that lower left ventricular ejection fraction (LVEF) correlates with poorer cognitive performance. Methods: We conducted a cross-sectional study of patients aged ≥18 years seen at a Heath System in 2022 who underwent both echocardiogram and cognitive assessment within one year. HF was classified into four groups based on 2022 American Heart Association HF guideline: No heart failure, HFpEF (HF with preserved LVEF), HFmrEF (HF with mid-range LVEF), and HFrEF (HF with reduced LVEF). Cognitive impairment was categorized using the Montreal Cognitive Assessment (MOCA) as normal (≥26), mild (18–25), moderate (10–17), and severe (40%. Adjusted odds of moderate to severe cognitive impairment were 1.14 for HFpEF, 0.99 for HFmrEF, and 2.81 for HFrEF compared to patients with no heart failure (trend-P=0.031, Table). Conclusions: Lower LVEF was independently associated with worse cognitive performance. Patients with HFrEF had a 2.5-fold higher risk of moderate to severe cognitive impairment. This association was not observed in patients with HFpEF or HFmrEF, suggesting differential cognitive effects across HF subtypes. Further studies are warranted to confirm these findings and evaluate the impact of interventions targeting EF and HF subtypes on cognitive outcomes.
Satyadev et al. (Thu,) reported a other. Lower left ventricular ejection fraction ≤40% was independently associated with a 2.49-fold higher adjusted odds of moderate/severe cognitive impairment compared to >40%.