Unmasking the impact of cytomegalovirus reactivation in people with advanced HIV disease with Pneumocystis Jirovecii pneumonia: does antiviral therapy change outcomes?

Key Points

• This research aims to explore the impact of cytomegalovirus (CMV) reactivation on patient outcomes in individuals with advanced HIV and Pneumocystis Jirovecii pneumonia (PJP).
• Observational study design
• Included hospitalized individuals with advanced HIV and PJP
• Assessed CMV DNA detection and antiviral therapy usage
• CMV DNA detection linked to worse outcomes in hospitalized patients
• Higher mortality observed in severe cases treated with anti-CMV therapy
• Findings highlight a potential relationship between CMV and in-hospital mortality