What question did this study set out to answer?

To develop a synthetic method for creating dihydrofuran-fused tropane-containing polycycles using rhodium(I).

February 2, 2026The Journal of Organic Chemistry0 citations

Rh(I)-Catalyzed Dearomative Cycloisomerization of Furan-Tethered o -Alkynylphenyl Nitrones to Tropane-Containing Polycycles

Key Points

To develop a synthetic method for creating dihydrofuran-fused tropane-containing polycycles using rhodium(I).
Rhodium(I)-catalyzed reaction
6-exo-dig cycloaddition and internal redox processes
Formation of azomethine ylides
Dearomative [3 + 2] cycloaddition
Successfully assembled dihydrofuran-fused polycycles
Demonstrated the efficiency of the catalytic process
Expanded the synthetic scope of tropane derivatives

Abstract

A synthetic method for the assembly of dihydrofuran-fused tropane-containing polycycles that relies on rhodium(I)-catalyzed 6-exo-dig cycloaddition/internal redox (IR)/azomethine ylide formation/dearomative 3 + 2 cycloaddition of furan-tethered o-alkynylphenyl nitrones has been developed.

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Cite This Study

Ji et al. (Thu,) studied this question.

synapsesocial.com/papers/6980fe13c1c9540dea80fc82 https://doi.org/https://doi.org/10.1021/acs.joc.5c02929

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