Splicing Factor SF3B4 Suppresses Pancreatic Cancer Growth and Migration by Inhibiting Autophagy

Key Points

• The research aims to evaluate the role of SF3B4 in regulating pancreatic cancer growth and autophagy.
• Analyzed SF3B4 expression in pancreatic cancer cells.
• Examined the effects of SF3B4 on autophagy and redox homeostasis.
• Investigated the impact of targeting the SF3B4-autophagy-ROS axis on cancer progression.
• SF3B4 was found to suppress pancreatic cancer cell growth and migration.
• Inhibition of autophagy was linked to SF3B4's tumor suppressor functions.
• Targeting the SF3B4-autophagy-ROS axis may help combat chemoresistance.