Investigating event-related potential (ERP) deviations in clinical high-risk populations for psychosis: a systematic review and meta-analysis

Key Points

• This research aims to evaluate event-related potential deviations as biomarkers for psychosis risk in clinical high-risk populations.
• Conducted a systematic review and meta-analysis of existing studies on ERP abnormalities in CHR populations.
• Focused on the duration-deviant mismatch negativity (MMN) as a key biomarker.
• Analyzed data to assess the predictive validity of ERPs for psychosis transition.
• Found significant ERP abnormalities, especially reduced duration-deviant MMN, in CHR populations.
• Established that these abnormalities can aid in early detection of psychosis risk.
• Indicated the potential of ERPs as low-cost, clinically accessible tools for risk stratification.