The prevalence of right-to-left shunting did not significantly correlate with the presence of active cancer in patients with ischemic stroke.
Cohort (n=491)
No
Does active cancer increase the prevalence of right-to-left shunting in young patients with ischemic stroke?
Active cancer is not associated with an increased prevalence of right-to-left shunting in young patients with ischemic stroke, challenging the hypothesis that paradoxical embolism is a primary mechanism for cancer-associated stroke.
Absolute Event Rate: 27.9% vs 29.7%
p-value: p=>0.05
ABSTRACT The presence of right-to-left shunt has been proposed as a prominent mechanism of paradoxical embolism in patients with active cancer. We conducted a retrospective observational study including patients presenting to the Ottawa Hospital between January 2020 and December 2022 with ischemic stroke with and without active cancer. Among 491 patients (36.9% female, median age 53), 43 (8.8%) had active cancer, with 12 (27.9%, 95% CI 15–44) having a shunt. Of 448 patients without cancer, 133 (29.7%, 95% CI 25–34) had a shunt. Overall, our finding does not support the hypothesis that cancer-associated stroke is related to right-to-left shunting.
Biglou et al. (Fri,) conducted a cohort in Ischemic stroke (n=491). The prevalence of right-to-left shunting did not significantly correlate with the presence of active cancer in patients with ischemic stroke.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: