Male sex was associated with a more pronounced improvement in left ventricular global longitudinal strain at 12 months post-PCI for ACS compared to female sex (ΔGLS -4.2% vs -2.9%; p=0.008).
Cohort (n=156)
Are there sex-related differences in left ventricular global longitudinal strain recovery in young patients with acute coronary syndrome and single-vessel disease after percutaneous coronary intervention?
Young men with ACS and single-vessel disease show significantly better left ventricular strain recovery at 12 months post-PCI compared to young women, suggesting a need for sex-specific post-ACS surveillance.
Absolute Event Rate: -4.2% vs -2.9%
p-value: p=0.008
Abstract Background Acute coronary syndrome (ACS) in young adults is an increasingly recognized entity, often associated with modifiable risk factors such as dyslipidemia. Limited data exist regarding longitudinal myocardial recovery using strain imaging in this population. Objectives To assess left ventricular myocardial strain recovery in young patients (≤40 years) with single-vessel coronary artery disease (CAD) following percutaneous coronary intervention (PCI) for ACS, and to evaluate sex-related differences in recovery patterns at 6 and 12 months. Methods We prospectively enrolled 156 patients aged 19–40 years (mean age: X ± SD; 112 men, 44 women) with first-time ACS and single-vessel CAD treated with successful PCI. All patients had segmental wall motion abnormalities on initial echocardiography. Left ventricular global longitudinal strain (GLS) was measured via speckle-tracking echocardiography at baseline, 6 months, and 12 months post-infarction. All patients had dyslipidemia but no significant comorbidities. Results GLS significantly improved over time in the overall cohort (baseline: –13.4 ± 2.1%; 6 months: –16.2 ± 1.9%; 12 months: –17.3 ± 1.7%; p0.001). When stratified by sex, male patients demonstrated a more pronounced improvement in GLS at both follow-up points compared to females (ΔGLS at 12 months: males –4.2 ± 1.5% vs. females –2.9 ± 1.3%, p=0.008). Baseline GLS values were similar between sexes. Conclusions Young patients with ACS and single-vessel CAD show significant improvement in left ventricular strain following PCI. However, men exhibit a more favorable recovery pattern than women, highlighting the need for sex-specific post-ACS surveillance and rehabilitation strategies in younger populations.
Dimitrova et al. (Thu,) conducted a cohort in Acute coronary syndrome and single-vessel coronary artery disease (n=156). Male sex vs. Female sex was evaluated on Change in left ventricular global longitudinal strain (ΔGLS) at 12 months (p=0.008). Male sex was associated with a more pronounced improvement in left ventricular global longitudinal strain at 12 months post-PCI for ACS compared to female sex (ΔGLS -4.2% vs -2.9%; p=0.008).