Background. Placental insufficiency is a clinical syndrome that causes fetal conditions and developmental disorders, caused by morphological and functional changes in the placenta. According to different statistical data, from 17% to 35% of pregnant women have this complication, and 14–17% patients with placental disorders later manifest in fetal growth restriction. Purpose – to identify the impact of placental insufficiency complex therapy with the inclusion of hyperbaric oxygenation courses on the trophic function of the placenta.in patients with breast cancer undergoing neoadjuvant chemotherapy. Materials and Methods. Within the framework of this study, 105 women were examined and divided into three groups. The main group consisted of 65 women with signs of threatened abortion, who were divided into group IIa, which received traditional treatment for placental insufficiency (35 women), and 30 women were assigned to group IIb, who underwent complex therapy for placental insufficiency with the addition of hyperbaric oxygenation courses. The control group included 40 women with a physiological course of the disease. All women underwent ultrasound biometry and Dopplerometry in uterine arteries with determination of the main blood flow indicators (Resistance Index, Pulsation Index, and Systolic-Diastolic Ratio, also placental thickness was measured, placental elastography was performed before treatment and 7–10 days after treatment. Results. Dopplerometry indicators in women from the main examination group were higher than in pregnant women with uncomplicated course of pregnancy. After therapy, Resistance Index, Pulsation Index, and Systolic-Diastolic Ratio normalized in the main study groups, so a stronger decrease occurred in group IIb than in group IIa. Placental thickness indicators were higher in groups of pregnant women with signs of threatened abortion than in control study group. Therefore after treatment Resistance Index, Pulsation Index, and Systolic-Diastolic Ratio decreased in group IIb more than in group IIa. Placenta density was higher in the groups of women with signs of placental insufficiency than in the control group. At the same time, after treatment, placental density indicators decreased in both group IIa and group IIb, but in women who underwent hyperbaric oxygenation courses, the decrease was more significant. The fetal head biparietal diameter in the control group was within 5–95% in 95% of women and in 2.5% the biparietal diameter measerments were within 5% and above 95%, respectively. In group IIa, before treatment, fetometry indicators in 2 women were lower by 5%, and in 1 they were higher by 95%, which amounted to 5.7% and 2.85%, respectively, while in group IIb, in 6.7% of the examined indicators of biparietal diameter, abdominal circumference and FL were within less than 5% for this term, and 3.3% more than 95% for this term. At the same time, 7–10 days after the therapy, the group of patients who underwent courses of hyperbaric oxygenation amounts of fetometry indicators were outside the limits by 5% decreased to 2.85% in the IIa group of examined women, and to 3.3% in the IIb group. The changes are not very indicative due to the fact that the biometric indicators of the fetus respond when placental insufficiency is chronic and longlasting. Conclusions. In the course of this study, improvements in the trophic function of the placenta after treatment were carried out, they were more significant in the groups of women with placental insufficiency, who, in addition to the trivial usual treatment of this pathology, also received courses of hyperbaric oxygenation, this can be explained by the fact that barotherapy is pathogenetically determined.
SHCHERBINA et al. (Wed,) studied this question.