Herbal medicines have been extensively used in traditional systems of medicine for centuries to enhance immunity and maintain homeostasis. These natural remedies are rich in bioactive phytochemicals, which interact with various cellular and molecular pathways to modulate immune function. This review systematically explores the Immunomodulatory effects of selected herbal medicines, including Amla, Tulsi, Ashwagandha, Giloy, Turmeric, and Garlic. Detailed discussion is provided on their active constituents, such as polyphenols, alkaloids, flavonoids, and terpenoids, which contribute to antioxidant activity, cytokine regulation, and enhancement of both innate and adaptive immunity. The paper also examines clinical evidence supporting the use of these herbs in managing infections, chronic inflammatory conditions, and immune deficiencies. Additionally, it highlights the role of herbal formulations in reducing oxidative stress, improving gut microbiota, and promoting overall systemic health. Emerging trends, including nanoformulations, standardized extracts, and novel drug delivery systems, are discussed to improve bioavailability and therapeutic efficacy. Safety profiles, dosage considerations, and potential herb-drug interactions are carefully reviewed to ensure practical application in healthcare.
1*Shaikh Sameer Ayub, 2Mr. Shikare S. H., 3Dr. Ganesh S. Tolsarwad (Sun,) studied this question.