ABSTRACT This work explores the synthesis of Cyclo3mer 1a obtained by the acid‐catalyzed condensation reaction of 1,5‐di(1 H ‐pyrrol‐2‐yl)anthracene with pentafluorobenzaldehyde in the presence of trifluoroacetic acid. Because of the larger cavity size and multiple sites for coordination, cyclo3mer underwent smooth BF2 complexation which showed a triangle‐like conformation based on the DFT optimization results. DFT analysis and solution state 1H NMR studies reveal the twisted C3 symmetric structure of the macrocycle 1a. Upon addition of enantiopure D and L mandelic acids, macrocycle 1a showed chiral response in CD spectra due to chirality induction.
Nambiar et al. (Sat,) studied this question.