An oxidative cleavage-based HCR-CRISPR/Cas12a biosensor for highly sensitive detection of hypochlorous acid

Key Points

• The aim is to develop a highly sensitive biosensor for detecting hypochlorous acid using oxidative cleavage and CRISPR/Cas12a technology.
• Constructed an oxidative cleavage-based HCR-CRISPR/Cas12a biosensor
• Focused on hypochlorous acid detection
• Achieved highly sensitive detection of hypochlorous acid
• Demonstrated effectiveness of biosensor compared to traditional methods