ABSTRACT The precise regulation of the dissolution and ion release of borate‐based glasses is essential for optimizing their potential in various applications, including antimicrobial materials, angiogenesis, and resorbable medical uses. However, the multicomponent interactions among network modifiers that govern these behaviors remain insufficiently resolved. In this study, a composition‐response mapping strategy was employed to systematically evaluate 16 multicomponent borate networks. Utilizing a design‐of‐mixture (DoM) approach, the individual and interaction effects of the modifiers were examined with respect to mass loss and ion release kinetics under simulated physiological conditions. This approach delivers a composition‐response map for the studied system and a mechanistic foundation to expedite the development of borate‐based formulations. The extent of dissolution varied from 20%–72% at 10 min to between 85% and 100% at 24 h. Statistical modeling indicated that dissolution is governed by modifier synergy rather than by concentration alone. For example, Ca 2 + moderated reactivity, F − suppressed long‐term mass loss, and Ag + accelerated ion exchange. The distinct kinetic profiles for the release of B, Ca, Ag, and F demonstrated compositionally adjustable transitions between transient and relatively more stabilized dissolution states. Collectively, these data establish a comprehensive map linking composition to function, enabling precise control over the degradation and ion‐release behavior. This framework enables the rational engineering of borate‐glass biomaterials that resorb with defined kinetics and can be functionally tailored for various therapeutic applications.
Andrea et al. (Fri,) studied this question.