A FibroSURE score >0.74 was associated with a significantly increased hazard of death or transplant in adults with Fontan circulation (HR 3.26; 95% CI 1.62-6.59; p=0.001).
Cohort (n=334)
No
Do non-invasive biomarkers of liver disease predict transplant-free survival in adults with Fontan circulation?
Higher scores on non-invasive liver fibrosis biomarkers (FibroSURE, APRI, FIB-4, MELD-XI) are associated with an increased risk of death or transplant in adults with Fontan circulation.
Hazard Ratio: 3.26 (95% CI 1.62–6.59)
p-value: p=0.001
Background The Fontan procedure is associated with long-term cardiac and non-cardiac complications and early mortality. Recent data suggest that some fibrosis scores may offer prognostic insight for individuals with Fontan circulation. This study aimed to investigate whether biomarkers of liver fibrosis can predict transplant-free survival in Fontan circulation. Methods This was a retrospective observational cohort study of 334 adults with Fontan circulation who had FibroSURE testing between 2008 and 2022 at a large-volume adult congenital heart disease centre. FibroSURE score, Aminotransferase-to-Platelet Ratio Index (APRI), fibrosis-4 (FIB-4) and Model for End-stage Liver Disease eXcluding INR (international normalised ratio) (MELD-XI) were recorded and analysed against clinical outcomes. Results There were 664 FibroSURE results during the study period with 83 (13%) above the nominal cut-off predicting cirrhosis (>0.74). There were 37 deaths (11%) and four transplants (1%) over a median follow-up of 5.6 years (IQR 2.7–9.9). After adjusting for age at FibroSURE and history of hepatitis C, each 0.1 increase in FibroSURE score remained associated with a 1.19-fold increased hazard of death or transplant (95% CI 1.02 to 1.40, p=0.032), and FibroSURE >0.74 remained associated with a 3.26-fold increased hazard of death or transplant (95% CI 1.62 to 6.59, p=0.001). In 314 patients where FibroSURE, APRI, FIB-4 and MELD-XI were all available, FibroSURE >0.74 (HR 5.11, 95% CI 2.66 to 9.83, p0.5 (HR 2.56, 95% CI 1.36 to 4.81, p=0.004), FIB-4 >1.45 (HR 5.07, 95% CI 2.67 to 9.64, p18 (HR 24.1, 95% CI 5.51 to 106, p<0.001) were all associated with increased hazard of death or transplant. Conclusions Higher FibroSURE, APRI, FIB-4 and MELD-XI are associated with increased hazard of death or transplant in Fontan circulation.
Collier et al. (Fri,) conducted a cohort in Fontan circulation (n=334). FibroSURE score >0.74 vs. FibroSURE score ≤0.74 was evaluated on death or transplant (HR 3.26, 95% CI 1.62-6.59, p=0.001). A FibroSURE score >0.74 was associated with a significantly increased hazard of death or transplant in adults with Fontan circulation (HR 3.26; 95% CI 1.62-6.59; p=0.001).