Absence of standard modifiable cardiovascular risk factors was associated with a higher unadjusted proportion of LAD coronary calcification, which attenuated after multivariable adjustment.
Cohort
Does the absence of standard modifiable cardiovascular risk factors (SMuRFless status) associate with a disproportionate atherosclerotic burden in the left anterior descending coronary artery compared to individuals with at least one risk factor?
While SMuRFless individuals appear to have a higher unadjusted proportion of coronary calcification in the LAD, this difference is largely explained by other demographic and inflammatory factors.
SMuRFless MESA participants had a higher unadjusted proportion of coronary calcification in the LAD compared SMuRF≥1 participants; however, this associated attenuated after multivariable adjustment. Further research is warranted to better understand the development of atherosclerotic CAD in SMuRFless individuals, and biological relevance and potentially different susceptibility at the epicardial segment level.
Gray et al. (Thu,) conducted a cohort in Atherosclerotic coronary artery disease. Absence of standard modifiable cardiovascular risk factors (SMuRFless) vs. Presence of ≥1 standard modifiable cardiovascular risk factor (SMuRF≥1) was evaluated on Proportion of coronary calcification in the left anterior descending coronary artery (LAD). Absence of standard modifiable cardiovascular risk factors was associated with a higher unadjusted proportion of LAD coronary calcification, which attenuated after multivariable adjustment.
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