Overexpression of FoxO3a in the dentate gyrus alleviates CUS-induced anxiety- and depression-like behaviors and cognitive impairment

Key Points

• The study aims to explore how FoxO3a influences anxiety, depression-like behaviors, and cognitive function following chronic unpredictable stress (CUS).
• Examined the effects of FoxO3a overexpression in the dentate gyrus of animal models.
• Assessed behavior using anxiety and depression-like tests after inducing CUS.
• Analyzed cellular changes related to oxidative stress, inflammation, and synaptic plasticity.
• FoxO3a overexpression showed reduced anxiety and depression-like behaviors in the models.
• Cognitive impairments associated with CUS were lessened with increased FoxO3a levels.
• Downregulation of FoxO3a contributed to oxidative stress and inflammation in the dentate gyrus.