Liraglutide alleviates sepsis-associated encephalopathy via attenuating neuronal damage, glial cell activation and mitochondrial dysfunction in a mouse model of sepsis

Key Points

• This research aims to investigate the neuroprotective effects of liraglutide on sepsis-associated encephalopathy (SAE).
• Utilized a mouse model of sepsis to evaluate liraglutide's effects
• Assessed neuronal damage, glial cell activation, and mitochondrial function
• Conducted comparative analyses between treated and untreated groups
• Liraglutide reduced neuronal damage observed in sepsis models
• Glial cell activation was significantly attenuated in treated mice
• Improvements in mitochondrial function were noted, correlating with enhanced neuroprotection