The clinical diagnostic value of miR-7110-5p and miR-4484 in carotid artery stenosis and their mediation of ox-LDL-induced cell injury through targeting IL16

Key Points

• The study aims to evaluate the diagnostic significance of miR-7110-5p and miR-4484 in carotid artery stenosis and their role in mediating cell injury.
• Assessment of miR-7110-5p and miR-4484 levels in carotid artery stenosis.
• Analysis of their impact on ox-LDL-induced injury in human carotid artery endothelial cells (HCAECs).
• Investigation of the regulatory effects on IL16.
• miR-7110-5p and miR-4484 demonstrate significant diagnostic value in carotid artery stenosis.
• Both microRNAs mediate injury in HCAECs caused by ox-LDL through the negative regulation of IL16.