Metal-and Photosensitizer-Free Hydrodifluoromethylation of Unactivated Alkenes via Acetamide-Activated Difluoromethyl Aryl Sulfones

Key Points

• The study aims to develop a metal-free method for hydrodifluoromethylation of unactivated alkenes using visible light.
• Utilized acetamide for activation of difluoromethyl aryl sulfones.
• Conducted hydrodifluoromethylation reactions under visible light conditions.
• Investigated the stability and reactivity of CF₂H reagents.
• Successfully achieved hydrodifluoromethylation without traditional metal catalysts.
• Showed efficiency through visible-light induction.
• Demonstrated the utility of acetamide in activating the reagents.