Objectives This prespecified interim analysis of the PRO-SPIRIT observational study compares the effectiveness and persistence of ixekizumab (IXE) with other biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) among patients with psoriatic arthritis (PsA) after 12 months of real-world treatment. Methods Data were collected from a multinational cohort (n=1192) initiating IXE or other b/tsDMARDs. Comparative effectiveness between IXE and other b/tsDMARDs was assessed using frequentist model averaging, with multiple imputation for missing data. Pairwise comparisons were performed between IXE and tumour necrosis factor inhibitors (TNFi), secukinumab (SEC), Janus kinase inhibitors and pooled interleukin (IL)-12/23i 18.8%). Versus pooled IL-12/23i and IL-23i, IXE patients were more likely to achieve cDAPSA remission (OR 2.0 (95% CI 1.2 to 6.0)) or very low disease activity (VLDA; OR 2.5 (1.1 to 13.6)), with greater pain reduction (least squares mean (LSM) (95% CI) −7.3 (−13.2 to −0.7)). Compared with TNFi, IXE patients exhibited greater BSA improvement (LSM (95% CI) −0.9 (−1.4 to −0.1)). IXE and SEC results were similar; most SEC patients received the 300 mg dose. Persistence rates were similar across groups, with varying reasons for discontinuation. Conclusions IXE patients had significantly greater odds of achieving cDAPSA remission and VLDA, plus greater pain reduction versus the pooled IL-12/23i and IL-23i group, with significant improvements in BSA versus TNFi. Treatment persistence was similar among all b/tsDMARDs.
Marzo-Ortega et al. (Thu,) studied this question.