Midface volumization and skin quality enhancement with a hyaluronic acid–polynucleotide hybrid filler: a 24-week prospective open-label study

Key Points

• To evaluate the effects of a hyaluronic acid-polynucleotide hybrid filler on midface volume and skin quality over 24 weeks.
• Conducted as a 24-week prospective open-label study
• Applied a hyaluronic acid-polynucleotide hybrid filler
• Assessed midface volume restoration and skin quality parameters including barrier function, hydration, and elasticity
• Significant improvements in midface volume restoration observed
• Concurrent enhancements in skin barrier function and hydration noted
• Elasticity of the skin improved significantly
• The filler was well tolerated with minimal adverse effects reported